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涓囦汉褰゛pp鎵嬫満鐗堜笅杞
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涓囦汉褰゛pp鎵嬫満鐗堜笅杞Ѷ

ʷýʷƵʷٷվĻƷٷ΢š΢ͷš־APPϲƵԼһѶšZAKER桢VIVA챨ڶýƽ̨ϵʺӪٷ΢žӪ˿ѽ ֹĿǰýƳԡʷΪͳһƷƵĴϵÿǧΪ߷ ڸƽֻ̨ҪʷͿԽӴʷķ

θʱԼ1/51еƷڻЧ룬ЯijЩضͻĻ˵Ч΢

2Ƕͷŵӡ

FDA׶ΣЧݣ˴NCCNָϸҲѽΪ2AƼҩΪGISTᣬҩѡ

ڡ΢š졿ڡѡġ顿¡ȡΪԡ ˡӪšӡֻҪСšʡġڡݡ͡᡿ܡۡ˿ġޡơ ¡ý塿šӡ䡿Ȼ桿顿롿ͷġʱ䡿ȡϡѸ١ԡ͸ͷġƽ̨桿򡿡Ͷ롿СС롿ԡԡġˡӪǡ㡿ڡݡ᡿ˡ

Ҷӱ̡ڡ⡿NCCNָϡθ䡿ʡءҪ¡С򡿡¡ҩסġ䡿֡GISTߡޡҩɡΡ #꡿⡿֡#

Ҷӱ̡ڡ⡿NCCNָϡθ䡿ʡءҪ¡С򡿡¡ҩסġ䡿֡GISTߡޡҩɡΡܡáרҡҶӱ󡿡ѧˡ񡿡ҽԺθ⡿ơΡ̡ڡΡҽʦʿʦСҽʦЭ᡿ء⡿ơҽʦ֡᡿᡿С١סѧ᡿(CSCO)θ䡿ʡרҵίԱ᡿ΡίԱСЭ᡿θ䡿ʡרҵίԱ᡿ΡίԱСҽʦЭ᡿⡿ơҽʦ֡᡿ࡿѧơЭ顿ҽʦίԱ᡿ΡίԱСҽʦЭ᡿⡿ơҽʦ֡᡿᡿ֱ⡿ơҽʦίԱ᡿ΡίԱСҽʦЭ᡿᡿ֱסרҵίԱ᡿١ܡѧ顿ΡίԱСϡ꡿סרҵίԱ᡿θס֡᡿ΡίԱСС͡ҽԺѧ᡿סרҵίԱ᡿ΡίԱСС͡ҽԺѧ᡿ˡ롿ǻ⡿ơרҵίԱ᡿ΡίԱڡСÿ꡿ԼС2-3򡿡ߡȷΪθ䡿ʡ(GIST)1 ⡿ǡһ֡ġסԼռСθ񡿡ԡסġ%-3%ԡθ͡СΪ2 ࡿȡΡθȡ㡿Ϊˡ֪ġ֡θ䡿ʡġ֪ȡ͡ءעȡϡ͡󡿡ڡߡԡ֢״ΡơģʽơЧˡ⡿ȫ桿

1ֱ2020ȫ׿ЯPDGFRA18ͻ(D842Vͻ)θ׼ҩavapritinibеϢùٴҽ뻼߶Ϊ֮ϲ Avapritinibضλͻľ׼ҩθڿ˾׼ʱ

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 ֵһǣavapritinibڼܹTKIƵθУҲͻԵЧ֣ORR22%޽չڸ¡

µNCCNָ(2019V6)УոҩѽָϣΪ2AƼPDGFRA18ͻ(D842Vͻ)θߡ NCCNָϵһƼҶΪͻЧйء ˽⣬ĿǰƷҪΪʹҰἤøƼ(TKIs)Чѡ PDGFRA18D842VͻΪһ32ߵĻعоʾ໼߶׼TKIҩУ͹ۻ(ORR)Ϊ0%3 D842V֮⣬׼GISTҩPDGFRA18ͻЧҲ롣

ýԭͶȼӴӦýʵѡ⡢ºͱ⣬ԭŴγͻ

ҲָTKIҩϣʵϣԼ̷ҩͻԭͻĻߣȱЧֶΣŴδ

avapritinibPDGFRA18ͻ(D842Vͻ)GISTORR84%ãλ޽չ(PFS)δﵽ4Чݿ˵ǰδеġ   Ҷڱʾ

־״ϴƣʷ׽ͷý #ָ#

ʷձһࡢȤζ֪Ϊļֵʱ¿ ΪһʷΪҪλݵͷſŴսʤϷܿ϶ܿʱаɯࡢʱڿʷý־ܱͣʷͷȡijɼҪԭ1ýڱ༭ϼֶԶ߸ʷڲϲǾʷ̸ʷʷ۹ţŵӽǿʷΧȵţʷɫȶ⣬ϣڱһʱý塣

ýԭͶȼӴӦýʵѡ⡢ºͱ⣬ԭĶŴγͻ

Ҷڱʾ

µNCCNָ(2019V6)УոҩѽָϣΪ2AƼPDGFRA18ͻ(D842Vͻ)θߡ NCCNָϵһƼҶΪͻЧйء ˽⣬ĿǰƷҪΪʹҰἤøƼ(TKIs)Чѡ PDGFRA18D842VͻΪһ32ߵĻعоʾ໼߶׼TKIҩУ͹ۻ(ORR)Ϊ0%3 D842V֮⣬׼GISTҩPDGFRA18ͻЧҲ롣

涓囦汉褰゛pp鎵嬫満鐗堜笅杞

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ʷýʷƵʷٷվĻƷٷ΢š΢ͷš־APPϲƵԼһѶšZAKER桢VIVA챨ڶýƽ̨ϵʺӪ΢žӪ˿ѽ ֹĿǰýƳԡʷΪͳһƷƵĴϵÿǧΪ߷ ڸƽֻ̨ҪʷͿԽӴʷķ

θʱԼ1/51еƷڻЧ룬ЯijЩضͻĻ˵Ч΢

΢źѹ£Ϊԡ ӪŶֻҪʵݣͲܵ˿ơ ýŶȻͷʱȽѸٳ͸ͷƽ̨ͶԵӪǸݰˡ

ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩ #ָ#

ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩܷרҶӱѧҽԺθνڡҽʦʿʦйҽʦЭسҽʦֻḱ᳤йٴѧ(CSCO)θרҵίԱίԱйЭθרҵίԱḱίԱйҽʦЭҽʦֻѧЭҽʦίԱίԱйҽʦЭҽʦֱֻҽʦίԱḱίԱйҽʦЭֱרҵίԱٹܱѧίԱйרҵίԱθֻḱίԱйоҽԺѧרҵίԱḱίԱйоҽԺѧ븹ǻרҵίԱḱίԱйÿԼ2-3߱ȷΪθ(GIST)1 һֺԼռθ%-3%θСΪ2 ȷΰθȹΪ֪֣θ֪Ⱥ͹עȽϵͣڼ߶Գ֢״ģʽЧ˽Ⲣȫ档

ݽͷĶ߿ζרŵԭݣµĹºͿɴ£ͬʱҲǵķ鹹дԭ򣬲Ұʷʷ ȡǵ֣Ϣйףöջ

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1ֱ2020ȫ׿ЯPDGFRA18ͻ(D842Vͻ)θ׼ҩavapritinibеϢùٴҽ뻼߶Ϊ֮ϲ Avapritinibضλͻľ׼ҩθڿ˾׼ʱ

 2Ƕͷŵӡ</p>ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩ #ָ#

ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩܷרҶӱѧҽԺθνڡҽʦʿʦйҽʦЭسҽʦֻḱ᳤йٴѧ(CSCO)θרҵίԱίԱйЭθרҵίԱḱίԱйҽʦЭҽʦֻѧЭҽʦίԱίԱйҽʦЭҽʦֱֻҽʦίԱḱίԱйҽʦЭֱרҵίԱٹܱѧίԱйרҵίԱθֻḱίԱйоҽԺѧרҵίԱḱίԱйоҽԺѧ븹ǻרҵίԱḱίԱйÿԼ2-3߱ȷΪθ(GIST)1 һֺԼռθ%-3%θСΪ2 ȷΰθȹΪ֪֣θ֪Ⱥ͹עȽϵͣڼ߶Գ֢״ģʽЧ˽Ⲣȫ档

FDA׶ΣЧݣ˴NCCNָϸҲѽΪ2AƼҩΪGISTᣬҩѡ

ΪδĶػ𽥴΢罻ΪĹתƵƽͷġ㷨+༭ƼĶƽ̨ϣ罻ĶתȤĶͷŴýĶһҪҲݴƽ̨

ݽͷĶ߿ζרŵԭµĹºͿɴ£ͬʱҲǵķ鹹дԭ򣬲Ұʷʷ ȡǵ֣Ϣйףöջ

1ֱ2020ȫ׿ЯPDGFRA18ͻ(D842Vͻ)θ׼ҩavapritinibеϢùٴҽ뻼߶Ϊ֮ϲ Avapritinibضλͻľ׼ҩθڿ˾׼ʱ

ݽͷĶ߿ζרŵԭݣĹºͿɴ£ͬʱҲǵķ鹹дԭ򣬲Ұʷʷ ȡǵ֣Ϣйףöջ

 θʱԼ1/51еƷڻЧ룬ЯijЩضͻĻ˵Ч΢

ԴˣҶӱڱʾǰհƼ˵avapritinibƵDZڹϻȨ϶ڹָƶԣҲܴIJο塣 ΪٴҽҺڴavapritinibͻЧҩΪ໼ߴϣ Ҷӱ˵Ȼھ׼˵ҪȷǷضе

΢źѹ£Ϊԡ ӪŶֻҪʵͲܵ˿ơ ýŶȻͷʱȽѸٳ͸ͷƽ̨ͶԵӪǸݰˡ

ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩ ##

ҶӱڽNCCNָθҪ£ҩ׸ı䲿GISTҩܷרҶӱѧҽԺθڡҽʦʿʦйҽʦЭسҽʦֻḱ᳤йٴѧ(CSCO)θרҵίԱίԱйЭθרҵίԱḱίԱйҽʦЭҽʦֻѧЭҽʦίԱίԱйҽʦЭҽʦֱֻҽʦίԱḱίԱйҽʦЭֱרҵίԱٹܱѧίԱйרҵίԱθֻḱίԱйоҽԺѧרҵίԱḱίԱйоҽԺѧ븹ǻרҵίԱḱίԱйÿԼ2-3߱ȷΪθ(GIST)1 һֺԼռθ%-3%θСΪ2 ȷΰθȹΪ֪֣θ֪Ⱥ͹עȽϵͣڼ߶Գ֢״ģʽЧ˽Ⲣȫ档

ýԭͶȼӴӦýʵѡ⡢ºͱ⣬ԭĶŴγͻ

NCCNָƼڽܰǰܻ⣬֢ҩܴﵽ׼ЧĿ

ͻֿɽһΪͬ͡ PDGFRAͻΪΪ18ͻ䣬ͻλ㲻ֿͬϸΪD842Vͻ䡣 KITPDGFRAҪָ֣θٴо򣬸춨ٴģʽ𲽴Ӵͳһ߷԰еģʽתơ ҶӱڱʾĿǰNCCNESMOCSCOָϾһǿƼθڽаҩǰӦлӼ⡣ ͹ۻ(ORR)84%İҩָƼⲿҩεĻ߽θ׼ʱڹȥ20УθγͰƵۺϵҩƵĽչͣʮǰ

ýԭͶȼӴӦýʵѡ⡢ºͱ⣬ԭĶŴγͻ</p>

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